Doctors on the frontline of the COVID-19 outbreak in New York City have published the first comprehensive review of the disease’s widespread effects on organ systems beyond the lungs. They also provide guidelines for managing these diverse effects. At the time of writing, globally, there have been more than 13 million confirmed cases of COVID-19, the illness that the coronavirus SARS-CoV-2 causes, and more than 570,000 deaths. While experts initially thought that the illness was principally a respiratory infection, doctors treating critically ill patients quickly recognized that its effects are far more widespread. n early March 2020, there was little clinical guidance for doctors treating the effects of COVID-19 outside the lungs, so Gupta decided to combine the findings that were emerging from early studies with what she and other doctors were learning on the ground. Gupta and her colleagues at Columbia collaborated with doctors across the United States to create the first comprehensive clinical guidelines on the disease’s non-respiratory symptoms. They summarize how the disease manifests in particular organ systems, the possible causes, and management options.